Born in Italy, Lucrezia Drei joined the Academy of La Scala in Milan. She participated in numerous concerts and operas conducted by renowned conductors such as Georges Prêtre, Lorin Maazel, Riccardo Muti, Zubin Mehta and Gustavo Dudamel. At the age of thirteen, she was acclaimed on the stage of La Scala in Milan in Janaček's The Cunning Little Vixen under the baton of Sir Andrew Davis. In parallel to her opera singing studies, she studied the flute and obtained a master's degree in music and neuroscience at the University of Milan. At a very young age she sang Flora in Benjamin Britten's The Turn of the Screw and the Blue Fairy in Respighi's Sleeping Beauty. She won several international competitions and began her international career as Susanna in Le Nozze di Figaro. She distinguished herself in the roles of Gilda (Rigoletto) and Corinna (Il viaggio a Reims) at the Rossini Festival in Pesaro and at the Varona Arena. She sang Oscar in Verdi's Un ballo in maschera, Nannetta in Falstaff with Joan Pons in Majorca. In Trieste she sang the role of Pamina in Die Zauberflöte, then the First Lady in Graham Vick's production at the Macerata Festival. Her repertoire also includes the roles of Fanny in Rossini's La Cambiale di matrimonio, Fiordiligi in Cosi fan tutte, Zerlina in Mozart's Don Giovanni. In Tokyo, Palermo and Toulon, she sang the role of Adina in Donizetti's L'Elisir d'amore.